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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Furanolactone</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p><b>Furanolactone</b> sind chemische Verbindungen aus der Klasse der <a href="Naturstoffe" class="mw-redirect" title="Naturstoffe">Naturstoffe</a>. Sie weisen sowohl einen <a href="Furan" title="Furan">Furanring</a> als Rest auf, als auch die funktionelle Gruppe der <a href="Lactone" title="Lactone">Lactone</a>.
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<div class="mw-heading mw-heading2"><h2 id="Vertreter">Vertreter</h2></div>
<p>Die Verbindungen der Furanolactone kommen ausschließlich in sehr komplexen chemischen Strukturen vor. Bekannte Vertreter dieser Stoffklasse sind:
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<ul><li>die <a href="Salvinorine" title="Salvinorine">Salvinorine</a><sup id="cite_ref-Harding_1-0" class="reference"><a href="#cite_note-Harding-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>, wie z. B. <a href="Salvinorin_A" title="Salvinorin A">Salvinorin A</a></li>
<li>Columbin</li>
<li>die <a href="Limonoide" title="Limonoide">Limonoide</a>, wie z. B. <a href="Limonin" title="Limonin">Limonin</a></li></ul>
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<td>Salvinorin A
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<td>Columbin
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<td>Limonin
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<div class="mw-heading mw-heading2"><h2 id="Vorkommen">Vorkommen</h2></div>
<p>Wie viele Naturstoffe kommen diese Verbindungen in den Bestandteilen zahlreicher Pflanzen vor. So kommt Limonin beispielsweise in Orangenkernen vor<sup id="cite_ref-Koller1936_2-0" class="reference"><a href="#cite_note-Koller1936-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> und Columbin ist Bestandteil der <a href="Kalumba" title="Kalumba">Kalumbawurzel</a> (als Arzneimittel Calumbae Radix genannt).<sup id="cite_ref-Kohno_3-0" class="reference"><a href="#cite_note-Kohno-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Swaminathan_4-0" class="reference"><a href="#cite_note-Swaminathan-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
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<li id="cite_note-Harding-1"><span class="mw-cite-backlink"><a href="#cite_ref-Harding_1-0">↑</a></span> <span class="reference-text">W. W. Harding, M. Schmidt, K. J. Tidgewell, P. Kannan, K. G. Holden, C. M. Dersch, R. B. Rothman, T. E. Prisinzano: <i>Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring</i>, Bioorganic & Medicinal Chemistry Letters, Nr. 16, 2006, S. 3170–3174, <a href="https://doi.org/10.1016/j.bmcl.2006.03.062" class="extiw external" title="doi:10.1016/j.bmcl.2006.03.062">doi:10.1016/j.bmcl.2006.03.062</a>.</span>
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<li id="cite_note-Koller1936-2"><span class="mw-cite-backlink"><a href="#cite_ref-Koller1936_2-0">↑</a></span> <span class="reference-text">G. Koller, H. Czerny: <i>Über das Limonin, den Bitterstoff der Orangenkerne.</i> In: <i><a href="Monatshefte_f%C3%BCr_Chemie_und_verwandte_Teile_anderer_Wissenschaften" class="mw-redirect" title="Monatshefte für Chemie und verwandte Teile anderer Wissenschaften">Monatshefte für Chemie und verwandte Teile anderer Wissenschaften</a>.</i>, Nr. 67, 1936, S. 248–268, <a href="https://doi.org/10.1007/BF0271602" class="extiw external" title="doi:10.1007/BF0271602">doi:10.1007/BF0271602</a>.</span>
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<li id="cite_note-Kohno-3"><span class="mw-cite-backlink"><a href="#cite_ref-Kohno_3-0">↑</a></span> <span class="reference-text">H. Kohno, M. Maeda, M. Tanino, Y. Tsukio, N. Ueda, K. Wada, S. Sugie, H. Mori, T. Tanaka: <i>A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis</i>, Acta Crystallographica Section C, Nr. 45, 1989, S. 300–303, <a href="https://doi.org/10.1016/s0304-3835(02)00159-3" class="extiw external" title="doi:10.1016/s0304-3835(02)00159-3">doi:10.1016/s0304-3835(02)00159-3</a>.</span>
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<li id="cite_note-Swaminathan-4"><span class="mw-cite-backlink"><a href="#cite_ref-Swaminathan_4-0">↑</a></span> <span class="reference-text">K. Swaminathan, U. C. Sinha, S. Ramakumar, R. K. Bhatt, B. K. Sabate: <i>Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers</i>, <a href="Cancer_Letters" title="Cancer Letters">Cancer Letters</a>, Nr. 138, 2002, S. 131–139, <a href="https://doi.org/10.1107/s0108270188010583" class="extiw external" title="doi:10.1107/s0108270188010583">doi:10.1107/s0108270188010583</a>.</span>
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